A useful and accessible work, this book introduces readers to Augustine by placing his life and central teachings in the context of his place and time. It displays the development of Augustinianism in a way that is at once chronological, biographical and philosophical, offering readers a better sense of Augustine as a person and a thinker.

ABSTRACT Although Kairos in Greek mythology is often depicted as the winged son of Zeus who grants to those who lay hold of his single lock of hair their once-in-a-lifetime opportunity, in traditional African American culture, particularly when it comes to speech, Kairos is essentially family. Given how much African American speakers depend on seizing the moment to invoke spiritual connections, emit laughter, and profess the truth, Kairos, or what we might call CPT (“Colored People’s Time”), can be summoned almost (...) at will. One of the African American discourses this article will use to illustrate this point is Call and Response, a verbal exchange in which speakers and listeners attune to one another and to the timeliness of an event. Martin Luther King Jr.’s “I Have a Dream” speech was such an event, but it wouldn’t have been so were it not for the timely responding of his favorite gospel singer, Mahalia Jackson. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Guest Editor's Introduction:A Moment for KairosTina SkouenHow does one describe a crucial moment, a moment that calls for action? What kinds of time are opened, disclosed, or foreclosed in such moments? This section explores a concept that has a long history in rhetoric and philosophy, but which is urgently called for now, in a time that many think of as critical, catastrophic, or even apocalyptic. Changes in the economy, (...) climate, and the state of our democracies demand urgent attention, and while people disagree on the course to be taken, there is a sense that—this is it!—now is the time. The concept of kairos (from ancient Greek καιρός) comprises both a critical time and a perfect opportunity; it is the right moment to act, even though the word could also be interpreted in a more general sense as referring to the issue of right timing. Considered as "one of the most untranslatable of Greek words," kairos is perhaps related to the verb kurō, "to meet" or "meet accidentally," as when an arrow meets a target, suggesting that there is a spatial component in the temporal kairos.1 The spatial dimension shines through in the earliest uses of the term discussed in both SeungJung Kim's article on ancient Greek visual arts and Robert Sullivan's article on Isocrates (436–338 BCE). According to Sullivan's survey, Isocrates most often employs the word to refer to a specific situation, occasion, state of affairs, or set of circumstances.How do you recognize, let alone seize, this kind of moment, though? The best-known depiction of this difficulty is a portrait of Kairos personified that dates back to Lysippos in the fourth century BCE, reconstructed visually in three dimensions in Kim's essay. In Greek mythology Kairos is the god of golden opportunities, which (as we all know!) tend to pass by too quickly. The portrait shows a winged figure with a flowing forelock that ideally gives you something to hold on to. I like to imagine that if you [End Page 267] manage to arrest this passing instant, time itself comes to an abrupt halt, which throws Kairos's hair out in front of his face.Of course, people do not necessarily see it as positive when someone appears to have captured the moment. At the kairos symposium hosted by art historian Barbara Baert in Brussels in October 2018, W. J. T. Mitchell held up a picture of President Donald Trump's sculpted forelock to illustrate that it all depends on the perspective. Turning the familiar Greek portrait into an image of the opportunist, Mitchell reminded all of us that had gathered to celebrate the legacy of kairos in iconographic, philosophical, theological, semantic, historical, and anthropological studies, of the ethical issues arising in such moments. The question of moral accountability is bound to come up, whether one takes kairos to refer to the act of seizing the moment, involving some form of decision, or to the moment itself, the kairos, which some might claim just seized upon them and carried them away.As Debra Hawhee and Erik Charles White before her have argued, kairos does not seem to be confined by the subjective reason operating in a "rhetorical situation," but it depends on "the forces pushing on the encounter," in addition to instinct and intuition, and possibly on habitual impulses springing from experience (Hawhee 2002, 24–25; White 1987; reconsidered by Brod 2021). Audiences may also have a significant role to play, as Kermit Campbell underscores in his discussion of the symbiosis of call and response in African American churches and his reflection on how Martin Luther King's speech at the 1963 March on Washington replied to a call: "Tell them about the dream, Martin."The moment of kairos may appear spontaneous and deliberate, both at the same time. The classical rhetoricians in fact insisted on the value of preparing for the unexpected, as we try to do in our current crisis management plans. In his essay, Sullivan documents the incredibly nuanced instructions Isocrates gave on how to exploit a prospective opening in all sorts of civic settings. From a rhetorical viewpoint, kairos can appear both as... (shrink)

Although serotonin, testosterone, and genes contribute to sociopathy, the relationships are probably indirect and subject to modifiers (e.g., present only under certain conditions of rearing and temperament). Age at menarche may be a marker variable as well as a causal factor. Since the genders differ in all four areas, sex differences in sociopathy represent a very complex interaction of these factors.

Given that his writings span well over forty years of maturing genius and that the audiences to whom these writings were directed were as varied as the Pelagians, Donatists, and Manichees, not to mention the Sunday flock, is it any wonder that Augustine’s thought found a home in Wittenberg as well as in Trent? T. Kermit Scott, associate professor of philosophy at Purdue University, begins his survey accordingly by acknowledging that “[p]art of the task of interpreting Augustine at this (...) late date is to make plausible how able and informed students have come to such divergent views”. (shrink)

In _"Masterpiece" Studies_ Kermit Champa offers new ways to interpret modernism that have previously been closed off by the application of the reigning art-historical methodologies to the study of the modernist achievement. He focuses on four separate phenomena—Manet's last Salon painting, _Bar at the Folies-Bergèr_e;_ L'Oeuvre_, Zola's novel about the realist/impressionist movement; Van Gogh's problematic versions of a single painting, _La Berceuse_; and the immanent "series" phenomenon of Monet's work of the period. Champa reveals the importance of music, in (...) particular Wagner's music, as a paradigm for later nineteenth-century French painting. He also shows the crucial significance of the concept of the masterpiece as thematized by Zola in his novel for our understanding of certain aspects of the art of Manet, Monet, and Van Gogh. Employing postformalist methodology, the book explores the conversation between works of art produced in close succession and elaborates an aesthetic context for that conversation. Champa also shows how paintings and fictional representations of paintings can announce their points in common, and it is out of this exploration that he radically redefines what constitutes "context.". (shrink)

The neuregulin gene encodes a series of polypeptide growth factors that can influence the growth state of target vertebrate cells in culture. Recently, three studies have explored the in vivo function of the neuregulin signaling system in mice by disrupting the genes encoding the neuregulin ligand(1) and two of its receptors, ErbB2(2) and ErbB4(3). Each of the genes is essential for development, and aberrations in cardiac and neural development are particularly prominent in mutant embryos. The observed defects, together with the (...) localization of expression of the neuregulin signaling components within these tissues, highlight a paracrine mechanism for neuregulin‐mediated intercellular communication. (shrink)

Stimulation of mitogenesis by the epidermal growth factor (EGF) operates through a pathway involving the receptor, the small G‐protein Ras and protein kinases of the MAP kinase cascade. It is proposed that two of the critical steps of that pathway utilize localization of components to the plasma membrane where Ras is located: recruitment of the nucleotide exchange protein Sos to the phosphorylated EGF receptor via a complex with the SH2/SH3‐containing protein Grb2 and recruitment of the protein kinase Raf to activated (...) Ras. Moreover, it is then proposed that Raf associates with the cytoskeleton at the membrane as it is being activated. Other signaling elements, including class I receptor kinases, nonreceptor tyrosine kinases and tyrosine phosphatases, are known to function at specific cellular sites. These observations have led us to propose that localization of signaling components, and particularly sites at membrane‐microfilament interfaces, play critical roles in cellular regulation. (shrink)

MUC1 and MUC4 are the two membrane mucins that have been best characterized. Although they have superficially similar structures and have both been shown to provide steric protection of epithelial surfaces, recent studies have also implicated them in cellular signaling. They act by substantially different mechanisms, MUC4 as a receptor ligand and MUC1 as a docking protein for signaling molecules. MUC4 is a novel intramembrane ligand for the receptor tyrosine kinase ErbB2/HER2/Neu, triggering a specific phosphorylation of the ErbB2 in the (...) absence of other ErbB ligands and potentiating phosphorylation and signaling through the ErbB2/ErbB3 heterodimeric receptor complex formed in the presence of neuregulin. In contrast, MUC1 has a highly conserved cytoplasmic tail, which binds β‐catenin, a key component of adherens junctions and a regulator of transcription, in a process that is tightly regulated by MUC1 phosphorylation. The specific localization of these membrane mucins to the apical surfaces of epithelial cells suggests that their signaling functions may be important as sensor mechanisms in response to invasion or damage of epithelia. BioEssays 25:66–71, 2003. © 2002 Wiley Periodicals, Inc. (shrink)

O‐glycosylation is the post‐translational process whereby carbohydrate is added to hydroxylated amino acids of proteins. The major O‐glycosylation pathway in animal cells is involved in the synthesis of oligosaccharides linked by N‐acetylgalactosamine to serine or threonine residues in ‘mucin‐type’ proteins or their analogs. In this review, we discuss the evidence for the cellular localization of the biosynthetic steps in this pathway and propose a simplified, consensus version. We also propose variations of the simple pathway to account for its heterogeneity and (...) variability in different cell types and differentiation states. (shrink)

Microfilament interactions with the plasma membranes of animal cells appear to vary with cell type and localization. In the erythrocyte, actin oligomers are associated with the membrane via spectrin and ankyrin. The ends of stress fibers in cultured cells, such as fibroblasts, are attached to the plasma membrane at focal adhesion sites and may involve the protein vinculin as a linking protein. In intestinal brush border microvilli a 110,000 dalton protein links the microfilament bundles to sites on the microvillus. A (...) transmembrane complex containing actin stably associated with a cell surface glycoprotein can be isolated from ascites tumor cell microvilli and can be obtained still associated with microfilaments by gentle extraction and gradient centrifugation of the microvilli. These varied interaction mechanisms are believed to be needed to satisfy the different structural and dynamic requirements of the particular systems. (shrink)

I denne teksten blir følgende spørsmål tatt opp til drøfting: Er det å ta medisinsk teknologi i bruk for å selektere et døvt barn mer etisk problematisk enn det motsatte; å bruke teknologien for å sikre seg et hørende barn? På bakgrunn av fire premisser konkluderer jeg med at både seleksjon for døvhet og for hørsel er tilnærmet like etisk problematisk. De fire premissene er 1) at seleksjonskriteriet sykdom eller skade bør erstattes av autentisitetsbetraktninger, 2) at døve og hørende har (...) samme potensial for autentisk livsutfoldelse, selv om det ikke kan avvises at døvhet kjennetegnes ved manglende hørsel, 3) at seleksjon innebærer fravalg av liv som har autentisk potensialitet enten som døv eller hørende, og 4) at dette fravalget involverer en etisk kostnad. Konklusjonen har enkelte andre implikasjoner og en restproblematikk som belyses avslutningsvis. (shrink)

Peirce’s system may be identified as one of a family of “organic memory” theories which flourished during the period in which he developed it, especially in the Monist journals which published much of his late work. “Organic memory” theories were vigorously opposed in their own day and are remembered in our own, if at all, only in connection with discredited theories such as racial memory and Lamarckian inheritance. When read in the context of their own time, however, “organic memory” theories (...) stand revealed as among modernity’s first attempts at a still-unrealized, post-nominalist re-foundation of science. Being thus closely related to Peirce’s own project both in time and in spirit, they deserve to be understood on their own terms. The synthesis of these theories in the book Das Gesetz der Serie (1919) by the Austrian biologist Paul Kammerer (1880-1926), a prominent representative of organized Monism's European branch, provides insight into the systematic unity of the various aspects of Peirce's thought, especially the close relationship between pragmatism and what is now called “emergence.”. (shrink)

Recent contributions to discussions on paediatric cochlear implantation in Norway indicate two mutually exclusive doctrines prescribing the best course of post-operative support for a child with cochlear implants; bilingually with sign language and spoken language simultaneously or primarily monolingually with speech only. This conflict constitutes an ethical problem for parents responsible for choosing between one of the two alternatives. This article puts forth the precautionary principle as a possible solution to this problem. Although scientific uncertainty exists in the case of (...) both doctrines, there exists a scenario of possible irreversible harm to some of the children habilitated monolingually. An application of the precautionary principle may hence suggest that it is rational to agree on the bilingual approach, at least for the time-being. (shrink)

This text presents an overview of the bioethical debate on pediatric cochlear implants and pays particular attention to the analysis of the Deaf critique of implantation. It dismisses the idea that Deaf concerns are primarily about the upholding of Deaf culture and sign language. Instead it is argued that Deaf skepticism about child rehabilitation after cochlear surgery is well founded. Many Deaf people have lived experiences as subjects undergoing rehabilitation. It is not the cochlear technology in itself they view as (...) problematic, but rather the subsequent rehabilitation process. Because they themselves have experienced what they describe as harmful effects which relate above all to the idea of normalization, they have articulated worries for the new generations of deaf children in need of rehabilitation following cochlear implant surgery. These insights have attracted little attention, but could represent relevant ethical questions of which both practitioners and researchers in the field of implantation might be aware. (shrink)

(Statement of Responsibility) by Timothy S. Huebner.

Sometimes ordinary disagreements become deep as a result of epistemic injustice. The paper explores a hitherto unnoticed connection between two phenomena that have received ample attention in recent social epistemology: deep disagreement and epistemic injustice. When epistemic injustice comes into play in a regular disagreement, this can lead to higher-order disagreement about what counts as evidence concerning the original disagreement, which deepens the disagreement. After considering a common definition of deep disagreement, it is proposed that the depth of disagreements is (...) best understood as a matter of degree. Then, a case study of real-life disagreement is introduced: the disagreement about whether racism is a significant issue in the Netherlands, illustrated by the tradition of ‘Black Pete’. It is argued that there is disagreement about what counts as evidence in the case study because of two forms of epistemic injustice: testimonial and hermeneutical injustice. Specifically, there is disagreement about epistemic principles concerning whether private first-personal experience of racism is a weighty source of evidence in this domain, whether victims of racism count as important testifiers in this domain, and how to assess testimony that is not intelligible to you because it employs concepts and terminology you are unfamiliar with. By dismissing the relevant testimony and epistemic resources, the disagreement boils down to disagreement on the level of epistemic principles concerning,, and. Introducinginjustice-based deep disagreementhighlights moral and political aspects of disagreements that might seem factual. (shrink)

Entry on the Stanford Encyclopedia of Philosophy. A summary of the literature on whether externalism about thought content precludes non-empirical knowledge of one's own thoughts.

This paper introduces the Spider Vision Framework, a biomimetic approach to AI governance inspired by the dual visual systems of spiders. By integrating focused oversight (technical detail) with systemic awareness (societal context) and grounding both in virtue ethics—particularly prudence, justice, and adaptability—the framework addresses immediate technical risks while accounting for long-term societal implications. Comparative analyses with consequentialist and deontological models underscore virtue ethics’ emphasis on moral character, and the paper proposes pilot studies for empirical validation in healthcare AI and autonomous (...) vehicles. This integrated approach aims to foster an adaptive, ethically robust governance model, balancing precision and breadth to better align AI with the common good. Initial findings suggest a significant improvement in ethical compliance and stakeholder engagement when dual-focus oversight is integrated into existing AI systems. The framework recommends targeted pilot implementations across diverse regulatory environments to ensure robust, context-specific outcomes. (shrink)

This careful and engaging introduction to Aristotle equips readers of ancient philosophy and classics with an intellectual map that will guide their further exploration within the terrains of Aristotelian philosophy and logic. The book does not seek to provide a verdict or to persuade the reader of the usefulness of Aristotle's ideas. Instead it offers a comprehensive introduction to key philosophical areas while situating the reader within the ongoing intellectual debates on Aristotle's significance and relevance. Crowley's book allows an overview (...) of Aristotle's contributions and includes discussions on the Organon, the epitome of his logical treatises, his works on biology, nature and causation, metaphysics, citizenship, ethics and eudaimonia. The book is a valuable tool for readers interested in becoming acquainted with the work of Aristotle but most importantly for those who are keen to understand his many interpretations. (shrink)

Chalmers (2018) considers a wide range of possible responses to the meta-problem of consciousness. Among them is the ignorance hypothesis -- the view that there only appears to be a hard problem because of our inadequate conception of the physical. Although Chalmers quickly dismisses this view, I argue that it has much greater promise than he recognizes. The plausibility of the ignorance hypothesis depends on how exactly one frames the 'problem intuitions' that a solution to the meta-problem must explain. I (...) argue that problem intuitions are hybrid intuitions that encompass one's intuitive take on the phenomenal and one's intuitive take on the physical. The ignorance hypothesis undermines the second half of these hybrid intuitions. I show how the ignorance hypothesis is preferable to the alternatives and attempt to explain why there is such widespread resistance to this promising position. (shrink)

This paper demonstrates the undecidability of a number of logics with quantification over public announcements: arbitrary public announcement logic, group announcement logic, and coalition announcement logic. In APAL we consider the informative consequences of any announcement, in GAL we consider the informative consequences of a group of agents all of which are simultaneously making known announcements. So this is more restrictive than APAL. Finally, CAL is as GAL except that we now quantify over anything the agents not in that group (...) may announce simultaneously as well. The logic CAL therefore has some features of game logic and of ATL. We show that when there are multiple agents in the language, the satisfiability problem is undecidable for APAL, GAL, and CAL. In the single agent case, the satisfiability problem is decidable for all three logics. (shrink)

An interpretation is offered of Thrasymachus' account of the nature of justice and just action in book I of the 'Republic' which is internally consistent throughout on all important points. Just action is not defined in terms of its practical consequences, as many commentators assume, but rather in terms of its logical consequences 'vis-a-vis' just agents. When one man acts justly towards another, the performance of the just act renders the just agent vulnerable to unfair or unjust exploitation by those (...) with whom he deals. The "strong man", in Thrasymachus' sense, would thus never be a just man. It is argued that Socrates addresses himself to this position, but that, while the textual Thrasymachus is silenced, Socrates' best arguments are, in fact, inadequate to refute Thrasymachus. (shrink)

Umwelt theory is an expression of von Uexküll’s subjective biology and as such usually applied in analysis of individual animals, yet it is fundamentally relational and therefore also suitable for analysis of more complex wholes. Since the birth of the modern environmental movement in the 1960s, there has been growing scientific and political acknowledgement of there being a global environmental crisis, which today manifests itself as a climate change and biodiversity crisis. This calls for a multi-scale ecosemiotic approach to analysis (...) of human ecology at various levels and scales. In this article I explore to what extent ecosemiotic methodology, drawing on Umwelt theory and its consistently subjective perspective, can be applied in analysis of human ecology at different geographical and ecological scales ranging from the global to the local. The article incorporates a case study of human–animal relations in Mamirauá Sustainable Development Reserve in the Central Amazon. This is a seasonal floodplain forest area surrounded by rivers. I investigate aspects of the living conditions and ecology of the reserve, with a main focus on indigenous communities and the circumstances of two primate species, namely the red howler monkey and the black-headed squirrel monkey. I outline matrixes of levels of study in ecosemiotics, and scales in human ecology, and apply two scales to the Mamirauá case. These take an individual animal’s and an individual human being’s subjective experience as their respectively starting points. This allows for multi-scale studies of human ecology from complementary angles. (shrink)

There are at least three vaguely atomistic principles that have come up in the literature, two explicitly and one implicitly. First, standard atomism is the claim that everything is composed of atoms, and is very often how atomism is characterized in the literature. Second, superatomism is the claim that parthood is well-founded, which implies that every proper parthood chain terminates, and has been discussed as a stronger alternative to standard atomism. Third, there is a principle that lies between these two (...) theses in terms of its relative strength: strong atomism, the claim that every maximal proper parthood chain terminates. Although strong atomism is equivalent to superatomism in classical extensional mereology, it is strictly weaker than it in strictly weaker systems in which parthood is a partial order. And it is strictly stronger than standard atomism in classical extensional mereology and, given the axiom of choice, in such strictly weaker systems as well. Though strong atomism has not, to my knowledge, been explicitly identified, Shiver appears to have it in mind, though it is unclear whether he recognizes that it is not equivalent to standard atomism in each of the mereologies he considers. I prove these logical relationships which hold amongst these three atomistic principles, and argue that, whether one adopts classical extensional mereology or a system strictly weaker than it in which parthood is a partial order, standard atomism is a more defensible addition to one’s mereology than either of the other two principles, and it should be regarded as the best formulation of the atomistic thesis. (shrink)

Once one accepts that certain things metaphysically depend upon, or are metaphysically explained by, other things, it is natural to begin to wonder whether these chains of dependence or explanation must come to an end. This essay surveys the work that has been done on this issue—the issue of grounding and infinite descent. I frame the discussion around two questions: (1) What is infinite descent of ground? and (2) Is infinite descent of ground possible? In addressing the second question, I (...) will consider a number of arguments that have been made for and against the possibility of infinite descent of ground. When relevant, I connect the discussion to two important views about the way reality can be structured by grounding: metaphysical foundationalism and metaphysical infinitism. (shrink)